This high voltage electron micrograph shows the three-dimensional structure of the inactive X chromosome. I worked with Dr. Stan Gartler at the University of Washington Department of Genome Sciences, where we found conformational differences between active and inactive X chromosomes. To quote Stan Gartler: “She took some of the most beautiful high voltage electron micrographs of sex chromatin that have ever been made… one of these pictures [image above] has been reproduced in a textbook.” While in the Gartler group, I set up the lab’s in situ hybridization system, first using radioactivity (!) and then FISH.